


- POČETNA
- O NAMA
- AKTUALNO
- MEĐUNARODNE ASOCIJACIJE
- KONTAKT
- POVEZNICE
- PRAVA PACIJENATA
- ORGANIZACIJE
- Hrvatsko društvo za hematologiju hrvatskog liječničkog zbora (HRDH)
- Hrvatska kooperativna udruga za hematološke bolesti – KROHEM
- The European Hematology Association (EHA)
- The European Group for Blood and Marrow Transplantation (EBMT)
- The European Organisation for Research and Treatment of Cancer (EORTC)
- European LeukemiaNet
- The American Society of Hematology (ASH)
- The American Society for Blood and Marrow Transplantation (ASBMT)
- The International Society of Hematology (ISH)
- The American Society of Pediatric Hematology/Oncology (ASPHO)
- The Society for Hematology and Stem Cells (ISEH)
- The International Myeloma Foundation (IMF)
- The Society for Immunotherapy of Cancer (SITC)
- The International Society on Thrombosis and Haemostasis (ISTH)
- The Society for Hematopathology
- The American Society of Clinical Oncology (ASCO)
- The European Society for Medical Oncology (ESMO)
- ČASOPISI
HULL DONOSI BILTEN MPN RESOURCH FOUNDATION-A ZA MJESEC LIPANJ 2021. - POGLEDAJTE PREDAVANJE DR. SRĐANA VERSTOVŠEKA
Conference Highlights
Two significant conferences for the oncology and hematology research communities took place this month and each featured important content on MPNs.At the American Society of Clinical Oncology's (ASCO) 2021 Annual Meeting, the MPN research presented included updates on several significant clinical trials for MF, including SIMPLIFY-1 (Momelotinib, Sierra Oncology) and BOREAS (KRT-232, Kartos Therapeutics). BOREAS is a new phase 3 study designed to evaluate a first-in-class small molecule inhibitor of MDM2, called KRT-232, in MF patients who no longer benefit from treatment with a JAK inhibitor. A literature review on outcomes of allogeneic hematopoietic cell transplants for MF was also presented at ASCO 2021, as well as numerous abstracts on Selinexor—a drug currently in trials (XPORT-MF-035 and XPORT-MF-034) for the treatment of MF.
The European Hematology Association (EHA) Annual Congress also took place and brought virtual participants together from across the globe to share their latest findings and innovations in the field. Notable MPN updates included:
- Dr. Ruben Mesa's discussion about the SIMPLIFY-1 study and how Momelotinib may offer transfusion independence and improved overall survival for certain MF patients.
- Dr. Srdan Verstovsek's presentation on the benefits of Pelabresib in combination with Ruxolitinib. The two together appear to show significant spleen and symptom improvement over Ruxolitinib, alone, in this patient population.
- Dr. Abdulraheem Yacoub's overview of LIMBER-313: a phase 3 trial that explores Ruxolitinib plus Parsaclisib in MF patients with no previous JAK and PI3K inhibitor exposure.
EHA 2021 also featured content on managing the toxicity of JAK2 inhibitors, as well as trial updates for Imetelstat (IMbark, IMerge; Geron) and Navitoclax (REFINE; AbbVie).
Community News & Events
Blood On the TrailAvid hiker and PV patient, Gary Linehan, embarked on a 272-mile journey on June 22nd to build awareness about MPNs and raise funds for MPNRF. Be sure to follow Gary’s exciting 4-week adventure and join us in cheering him on each step of the way! You can read Gary’s story and show your support on his event page.
It's Not Too Late. Watch Today!Patient Empowerment Network (PEN) hosted a webinar on June 1st, called How to Play an Active Role in Your MPN Treatment and Care Decisions. The goal of this event was to help MPN patients engage with their healthcare team to receive the best treatment for their condition. The event featured MPN expert Dr. Naveen Pemmaraju and can be viewed on-demand today.
Treasure Sale to Benefit MPN Research FoundationIn support of her son who has Essential Thrombocythemia (ET), Peggy Patrick has been working hard to organize a special Treasure Sale fundraiser, with all proceeds going to MPNRF. She’s been collecting donated items from the public and is now hosting weekly Treasure Sales in the storefront of a former shoe store in downtown Virginia, MN. Learn more about Peggy’s fundraising efforts in this recent article by the Mesabi Tribune.
Featured Clinical Trials
Trial Name: PACIFICACompany: CTI BiopharmaStudy: Phase 3 study evaluating Pacritinib compared to physician's choice therapy in patients with MF and severe thrombocytopenia. This study was designed to use the Pacritinib 200 mg twice daily oral dose.Enrolling: Intermediate- to high-risk MF patients who have had no or limited exposure to any JAK2 inhibitor and who have severe thrombocytopenia (platelet count <50,000/µL). Participants treated with more than one JAK2 inhibitor are ineligible.
Trial Name: XPORT-MF-035Company: Karyopharm Therapeutics Inc.Study: Phase 2 study to evaluate Selinexor versus treatment of physician’s choice in participants with previously treated MF. Selinexor is orally administered and blocks the transport of several proteins involved in cancer-cell growth.Enrolling: MF patients who have had at least 6 months of treatment with a JAK 1 or 2 inhibitor. Individuals who have had previous treatment with Selinexor or other exportin 1 (XPO1) inhibitors are ineligible.
Welcome to MPNRF!
We are happy to introduce two new members of the MPNRF team!Kendra Waddington joined our team earlier this month as our new Director of Development. In this role, she will be working with individuals, families, foundations, and others to raise funds in support of MPN research and patients. She looks forward to connecting with the many members of our MPN community.Stephanie Fisher joins us July 1 and will be leading patient advocacy and biopharma engagement initiatives at MPNRF. She brings a wealth of experience to the team after having worked in rare diseases and advocacy roles. We are excited to welcome Stephanie into this new chapter with MPNRF!
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MPN Research Foundation (MPNRF)180 N Michigan Avenue, Suite 1870 | Chicago, IL 60601
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